Publications

2024

• Akash Mishra, Gelana Tostaeva, Maximilian Nentwich, Elizabeth Espinal, Noah Markowitz, Sabina Gherman, Jalen Winfield, Ashesh D. Mehta, Stephan Bickel. Motifs of human hippocampal and cortical high frequency oscillations structure processing and memory of naturalistic stimuli. bioRxiv. 2024.08.05.606665 (2024) PDF.
• Vishal Choudhari, Cong Han, Stephan Bickel, Ashesh D. Mehta, Catherine Schevon, Guy M. McKhann, Nima Mesgarani. Brain-Controlled Augmented Hearing for Spatially Moving Conversations in Multi-Talker Environments. Adv. Sci.. 11, 2401379 (2024) PDF.
• Maximilian Nentwich, Marcin Leszczynski, Charles E Schroeder, Stephan Bickel, Lucas C Parra. Intrinsic dynamic shapes responses to external stimulation in the human brain. bioRxiv. 2024.10.08.617305 (2024) PDF.
• Sabina Gherman, Marcin Leczinski, Stephan Bickel. Intracranial EEG. Cognitive Neuroscience Methods. Springer Nature. Book Chapter (2024).
• Akash Mishra, Serdar Akkol, Elizabeth Espinal, Noah Markowitz, Gelana Tostaeva, Elisabeth Freund, Ashesh D. Mehta, Stephan Bickel. Hippocampal sharp wave ripples and coincident cortical ripples orchestrate human semantic networks. bioRxiv. 2024.04.10.588795 (2024) doi:10.1101/2024.04.10.588795. PDF.
• Sabina Gherman, Noah Markowitz, Gelana Tostaeva, Elizabeth Espinal, Ashesh D. Mehta, Redmond G. O’Connell, Simon P. Kelly, Stephan Bickel. Intracranial electroencephalography reveals effector-independent evidence accumulation dynamics in multiple human brain regions. Nat Hum Beh. 8, 758–770 (2024).
• Kiki van der Heijden, Prachi Patel, Stephan Bickel, Jose L. Herrero, Ashesh D. Mehta, Nima Mesgarani. Joint population coding and temporal coherence link an attended talker’s voice and location features in naturalistic multi-talker scenes. bioRxiv. 2024.05.13.593814 (2024) doi:10.1101/2024.05.13.593814. PDF.
• Ruxue Gong, Stephan Bickel, Gelana Tostaeva, Fred A. Lado, Ashesh D. Metha, Ruben I. Kuzniecky, Leonardo F. Bonilha, Ezequiel L. Gleichgerrcht. Optimizing Surgical Planning for Epilepsy Patients With Multimodal Neuroimaging and Neurophysiology Integration: A Case Study. J. Clin. Neurophysiol. 41, 317–321 (2024).

2023

• Gavin Mischler, Menoua Keshishian, Stephan Bickel, Ashesh D. Mehta, Nima Mesgarani. Deep neural networks effectively model neural adaptation to changing background noise and suggest nonlinear noise filtering methods in auditory cortex. Neuroimage (2023) doi:10.1016/j.neuroimage.2022.119819. PDF.
• Vinay S Raghavan, James O’Sullivan, Stephan Bickel, Ashesh D Mehta, Nima Mesgarani. Distinct neural encoding of glimpsed and masked speech in multitalker situations. PLOS Biology 21, e3002128 (2023). PDF.
• Sabina Gherman, Noah Markowitz, Gelana Tostaeva, Elizabeth Espinal, Ashesh D. Mehta, Redmond G. O’Connell, Simon P. Kelly, Stephan Bickel. Intracranial electroencephalography reveals effector-independent evidence accumulation dynamics in multiple human brain regions. bioRxiv. 2023.04.10.536314 (2023) doi:10.1101/2023.04.10.536314. PDF.
• Menoua Keshishian, Serdar Akkol, Jose Herrero, Stephan Bickel, Ashesh D. Mehta, Nima Mesgarani. Joint, distributed and hierarchically organized encoding of linguistic features in the human auditory cortex. Nat. Hum. Behav. 7, 740–753 (2023).
• Marcin Leszczynski, Stephan Bickel, Maximilian Nentwich, Brian E. Russ, Lucas Parra, Peter Lakatos, Ashesh Mehta, Charles E. Schroeder. Saccadic modulation of neural excitability in auditory areas of the neocortex. Curr Biol 33, 1185-1195.e6 (2023).
• Maximilian Nentwich, Marcin Leszczynski, Brian E. Russ, Lukas Hirsch, Noah Markowitz, Kaustubh Sapru, Charles E. Schroeder, Ashesh D. Mehta, Stephan Bickel, Lucas C. Parra. Semantic novelty modulates neural responses to visual change across the human brain. Nat Commun 14, 2910 (2023).
• Arish Alreja, Michael J. Ward, Qianli Ma, Brian E. Russ, Stephan Bickel, Nelleke C. Van Wouwe, Jorge A. González-Martínez, Joseph S. Neimat, Taylor J. Abel, Anto Bagić, Lisa S. Parker, R. Mark Richardson, Charles E. Schroeder, Louis–Philippe Morency, Avniel Singh Ghuman. A new paradigm for investigating real-world social behavior and its neural underpinnings. Behav Res Methods 1–20 (2022) doi:10.3758/s13428-022-01882-9.
• BE Youngerman, MA Banu, F Khan, GM McKhann, CA Schevon, JR Jagid, I Cajigas, CB Theodotou, A Ko, R Buckley, JG Ojemann, JW Miller, AW Laxton, DE Couture, GS Popli, VP Buch, CH Halpern, S Le, AD Sharan, MR Sperling, AD Mehta, DJ Englot, JS Neimat, PE Konrad, SA Sheth, EG Neal, FL Vale, KL Holloway, EL Air, JM Schwalb, PF D'Haese, C. Wu. Long-term outcomes of mesial temporal laser interstitial thermal therapy for drug-resistant epilepsy and subsequent surgery for seizure recurrence: a multi-centre cohort study. J. Neurol., Neurosurg. Psychiatry 94, 879–886 (2023). PDF.
• R Broday-Dvir, Y Norman, M Harel, AD Mehta, R. Malach. Perceptual stability reflected in neuronal pattern similarities in human visual cortex. Cell Rep. 42, 112614 (2023). PDF.

2022

• Sam A Neymotin, Idan Tal, Annamaria Barczak, Monica N O’Connell, Tammy McGinnis, Noah Markowitz, Elizabeth Espinal, Erica Griffith, Haroon Anwar, Salvador Dura-Bernal, Charles E Schroeder, William W Lytton, Stephanie R Jones, Stephan Bickel, Peter Lakatos. Detecting spontaneous neural oscillation events in primate auditory cortex. Eneuro ENEURO.0281-21.2022 (2022) doi:10.1523/eneuro.0281-21.2022.
• Prachi Patel, Bahar Khalijhinejad, Jose L. Herrero, Stephan Bickel, Ashesh D. Mehta, Nima Mesgarani. Improved Speech Hearing in Noise with Invasive Electrical Brain Stimulation. J. Neurosci. 42, 3648–3658 (2022).
• Prachi Patel, Kiki van der Heijden, Stephan Bickel, Jose L. Herrero, Ashesh D. Mehta, Nima Mesgarani. Interaction of bottom-up and top-down neural mechanisms in spatial multi-talker speech perception. Curr Biol 32, 3971-3986.e4 (2022). PDF.
• Marcin Leszczynski, Stephan Bickel, Maximilian Nentwich, Brian E. Russ, Lucas Parra, Peter Lakatos, Ashesh Mehta, Charles E. Schroeder. Saccadic modulation of neural excitability in auditory areas of the neocortex. bioRxiv 2022.05.24.493336 (2022) doi:10.1101/2022.05.24.493336.

2021

• Jose L. Herrero, Alexander Smith, Akash Mishra, Noah Markowitz, Ashesh D. Mehta, Stephan Bickel. Inducing neuroplasticity through intracranial θ-burst stimulation in the human sensorimotor cortex. J Neurophysiol 126, 1723–1739 (2021).
• Chad Bouton, Nikunj Bhagat, Santosh Chandrasekaran, Jose Herrero, Noah Markowitz, Elizabeth Espinal, Joo-won Kim, Richard Ramdeo, Junqian Xu, Matthew F. Glasser, Stephan Bickel, Ashesh Mehta. Decoding Neural Activity in Sulcal and White Matter Areas of the Brain to Accurately Predict Individual Finger Movement and Tactile Stimuli of the Human Hand. Front Neurosci-switz 15, 699631 (2021). PDF.
• Santosh Chandrasekaran, Stephan Bickel, Jose L. Herrero, Joo-won Kim, Noah Markowitz, Elizabeth Espinal, Nikunj A. Bhagat, Richard Ramdeo, Junqian Xu, Matthew F. Glasser, Chad E. Bouton, Ashesh D. Mehta. Evoking highly focal percepts in the fingertips through targeted stimulation of sulcal regions of the brain for sensory restoration. Brain Stimul 14, 1184–1196 (2021). PDF.
• Bahar Khalighinejad, Prachi Patel, Jose L. Herrero, Stephan Bickel, Ashesh D. Mehta, Nima Mesgarani. Functional characterization of human Heschl’s gyrus in response to natural speech. Neuroimage 235, 118003 (2021). PDF.
• Santosh Chandrasekaran, Matthew Fifer, Stephan Bickel, Luke Osborn, Jose Herrero, Breanne Christie, Junqian Xu, Rory K. J. Murphy, Sandeep Singh, Matthew F. Glasser, Jennifer L. Collinger, Robert Gaunt, Ashesh D. Mehta, Andrew Schwartz, Chad E. Bouton. Historical perspectives, challenges, and future directions of implantable brain-computer interfaces for sensorimotor applications. Bioelectron. Med. 7, 14 (2021). PDF.
• Samuel A Neymotin, Idan Tal, Annamaria Barczak, Monica N. O’Connell, Tammy McGinnis, Noah Markowitz, Elizabeth Espinal, Erica Griffith, Haroon Anwar, Salvador Dura-Bernal, Charles E Schroeder, William W Lytton, Stephanie R Jones, Stephan Bickel, Peter Lakatos. Taxonomy of neural oscillation events in primate auditory cortex. Biorxiv 2020.04.16.045021 (2021) doi:10.1101/2020.04.16.045021.
• Datta-Chaudhuri, T. et al. The Fourth Bioelectronic Medicine Summit “Technology Targeting Molecular Mechanisms”: current progress, challenges, and charting the future. Bioelectron. Med. 7, 7 (2021).
• S Khuvis, EM Yeagle, Y Norman, S Grossman, R Malach, AD. Mehta. Face-Selective Units in Human Ventral Temporal Cortex Reactivate during Free Recall. J. Neurosci. 41, 3386–3399 (2021). PDF.
• S Khuvis, ST Hwang, AD. Mehta. Intracranial EEG Biomarkers for Seizure Lateralization in Rapidly-Bisynchronous Epilepsy After Laser Corpus Callosotomy. Front. Neurol. 12, 696492 (2021).

2020

• Shihab Shamma, Prachi Patel, Shoutik Mukherjee, Guilhem Marion, Bahar Khalighinejad, Cong Han, Jose Herrero, Stephan Bickel, Ashesh Mehta, Nima Mesgarani. Learning Speech Production and Perception through Sensorimotor Interactions. Cereb Cortex Commun 2, tgaa091- (2020).
• Idan Tal, Samuel Neymotin, Stephan Bickel, Peter Lakatos, Charles E. Schroeder. Oscillatory Bursting as a Mechanism for Temporal Coupling and Information Coding. Front Comput Neurosc 14, 82 (2020).
• E Ceolini, J Hjortkjær, Wong DDE, J O'Sullivan, VS Raghavan, J Herrero, AD Mehta, SC Liu, N. Mesgarani. Brain-informed speech separation (BISS) for enhancement of target speaker in multitalker speech perception. NeuroImage 223, 117282 (2020).
• VN Vakharia, RE Sparks, SB Vos, Y Bezchlibnyk, AD Mehta, JT Willie, C Wu, A Sharan, S Ourselin, JS. Duncan. Computer-assisted planning for minimally invasive anterior two-thirds laser corpus callosotomy: A feasibility study with probabilistic tractography validation. NeuroImage: Clin. 25, 102174 (2020).
• Liberto GM Di, C Pelofi, R Bianco, P Patel, AD Mehta, JL Herrero, A de Cheveigné, S Shamma, N. Mesgarani. Cortical encoding of melodic expectations in human temporal cortex. eLife 9, e51784 (2020).
• P Mégevand, MR Mercier, DM Groppe, Golumbic E Zion, N Mesgarani, MS Beauchamp, CE Schroeder, AD. Mehta. Crossmodal Phase Reset and Evoked Responses Provide Complementary Mechanisms for the Influence of Visual Speech in Auditory Cortex. J. Neurosci. 40, 8530–8542 (2020).
• M Keshishian, H Akbari, B Khalighinejad, JL Herrero, AD Mehta, N. Mesgarani. Estimating and interpreting nonlinear receptive field of sensory neural responses with deep neural network models. eLife 9, e53445 (2020).

2019

• Holdgraf, C. et al. iEEG-BIDS, extending the Brain Imaging Data Structure specification to human intracranial electrophysiology. Sci Data 6, 102 (2019).
• B Khalighinejad, JL Herrero, AD Mehta, N. Mesgarani. Adaptation of the human auditory cortex to changing background noise. Nat. Commun. 10, 2509 (2019).
• S Grossman, G Gaziv, EM Yeagle, M Harel, P Mégevand, DM Groppe, S Khuvis, JL Herrero, M Irani, AD Mehta, R. Malach. Convergent evolution of face spaces across human face-selective neuronal groups and deep convolutional networks. Nat. Commun. 10, 4934 (2019).
• Wu, C. et al. Effects of surgical targeting in laser interstitial thermal therapy for mesial temporal lobe epilepsy: A multicenter study of 234 patients. Epilepsia 60, 1171–1183 (2019).
• J O'Sullivan, J Herrero, E Smith, C Schevon, GM McKhann, SA Sheth, AD Mehta, N. Mesgarani. Hierarchical Encoding of Attended Auditory Objects in Multi-talker Speech Perception. Neuron 104, 1195-1209.e3 (2019).
• Norman, EM Yeagle, S Khuvis, M Harel, AD Mehta, R. Malach. Hippocampal sharp-wave ripples linked to visual episodic recollection in humans. Science 365 (2019).
• Huang, Y. et al. Intracortical Dynamics Underlying Repetitive Stimulation Predicts Changes in Network Connectivity. J. Neurosci. 39, 6122–6135 (2019).
• Han, C. et al. Speaker-independent auditory attention decoding without access to clean speech sources. Sci. Adv. 5, eaav6134 (2019).
• Flinker, A. et al. Spectrotemporal modulation provides a unifying framework for auditory cortical asymmetries. Nat. Hum. Behav. 3, 393–405 (2019).
• Grossman, S. et al. The Noisy Brain: Power of Resting-State Fluctuations Predicts Individual Recognition Performance. Cell Rep. 29, 3775-3784.e4 (2019).
• Akbari, H. et al. Towards reconstructing intelligible speech from the human auditory cortex. Sci. Rep. 9, 874 (2019).
• Lehner, K. et al. Validation of corpus callosotomy after laser interstitial thermal therapy: a multimodal approach. J. Neurosurg. 131, 1095–1105 (2019).

2018

• Kucyi, A. et al. Intracranial Electrophysiology Reveals Reproducible Intrinsic Functional Connectivity within Human Brain Networks. J Neurosci 38, 4230 4242 (2018).
• Benjamin, C. F. A. et al. Presurgical language fMRI: Clinical practices and patient outcomes in epilepsy surgical planning. Hum Brain Mapp 39, 2777–2785 (2018).
• Benjamin, C. F. A. et al. Presurgical language fMRI: Technical practices in epilepsy surgical planning. Hum Brain Mapp 39, 4032–4042 (2018).
• Herrero, J. et al. Breathing above the brain stem: volitional control and attentional modulation in humans. J. Neurophysiol. 119, 145–159 (2018).
• Keller, C. et al. Induction and Quantification of Excitability Changes in Human Cortical Networks. J. Neurosci. 38, 5384–5398 (2018).
• Patel, P. et al. Joint Representation of Spatial and Phonetic Features in the Human Core Auditory Cortex. Cell Rep. 24, 2051-2062.e2 (2018).
• Schwiedrzik, C. et al. Medial prefrontal cortex supports perceptual memory. Curr. Biol. 28, R1094–R1095 (2018).
• Opitz, A. et al. On the importance of precise electrode placement for targeted transcranial electric stimulation. NeuroImage 181, 560–567 (2018).

2017

• Mégevand, P. et al. The hippocampus and amygdala are integrators of neocortical influence: a cortico-cortical evoked potential study. Brain Connectivity brain.2017.0527 (2017) doi:10.1089/brain.2017.0527.
• Pruitt, R., Gamble, A., Black, K., Schulder, M. & Mehta, A. D. Complication avoidance in laser interstitial thermal therapy: lessons learned. J. Neurosurg. 126, 1238–1245 (2017).
• Golan, T. et al. Increasing suppression of saccade-related transients along the human visual hierarchy. eLife 6, e27819 (2017).
• Podvalny, E. et al. Invariant Temporal Dynamics Underlie Perceptual Stability in Human Visual Cortex. Curr. Biol. 27, 155–165 (2017).
• Du, V., Gandhi, S., Rekate, H. & Mehta, A. D. Laser interstitial thermal therapy: A first line treatment for seizures due to hypothalamic hamartoma? Epilepsia 58, 77–84 (2017).
• Ten, O. S. et al. Low-Frequency Cortical Oscillations Entrain to Subthreshold Rhythmic Auditory Stimuli. J. Neurosci. 37, 4903–4912 (2017).
• O’Sullivan, J. et al. Neural decoding of attentional selection in multi-speaker environments without access to clean sources. J. Neural Eng. 14, 056001 (2017).
• O’Sullivan, J. et al. Neural decoding of attentional selection in multi-speaker environments without access to separated sources. 2017 39th Annu. Int. Conf. IEEE Eng. Med. Biol. Soc. (EMBC) 2017, 1644–1647 (2017).
• Norman, Y., Yeagle, E., Harel, M., Mehta, A. & Malach, R. Neuronal baseline shifts underlying boundary setting during free recall. Nat. Commun. 8, 1301 (2017).
• Keller, C. et al. Tuning face perception with electrical stimulation of the fusiform gyrus. Hum. Brain Mapp. 38, 2830–2842 (2017).

2016

• Mercier, M. R. et al. Evaluation of cortical Local Field Potential diffusion in Stereotactic Electro-EncephaloGraphy recordings: a glimpse on white matter signal. Neuroimage 147, (2016).
• Fox, M. et al. Combining task-evoked and spontaneous activity to improve pre-operative brain mapping with fMRI. NeuroImage 124, 714–723 (2016).
• Hamberger, M. et al. Functional differences among stimulation-identified cortical naming sites in the temporal region. Epilepsy Behav. 60, 124–129 (2016).
• Golan, T. et al. Human intracranial recordings link suppressed transients rather than “filling-in” to perceptual continuity across blinks. eLife 5, e17243 (2016).
• Opitz, A. et al. Spatiotemporal structure of intracranial electric fields induced by transcranial electric stimulation in humans and nonhuman primates. Sci. Rep. 6, 31236 (2016).

2015

• Podvalny, E. et al. A unifying principle underlying the extracellular field potential spectral responses in the human cortex. J Neurophysiol 114, 505–519 (2015).
• Groppe, D. M. et al. Dominant frequencies of resting human brain activity as measured by the electrocorticogram. Neuroimage 79, 1 11 (2015).
• Noy, N. et al. Ignition’s glow: Ultra-fast spread of global cortical activity accompanying local “ignitions” in visual cortex during conscious visual perception. Conscious Cogn 35, 206 224 (2015).
• Noy, N. et al. Intracranial recordings reveal transient response dynamics during information maintenance in human cerebral cortex. Hum Brain Mapp 36, 3988 4003 (2015).
• Haegens, S. et al. Laminar Profile and Physiology of the α Rhythm in Primary Visual, Auditory, and Somatosensory Regions of Neocortex. J. Neurosci. 35, 14341–14352 (2015).
• Yaffe, R. et al. Physiology of functional and effective networks in epilepsy. Clin. Neurophysiol. 126, 227–236 (2015).

2014

• Keller, C. J., Bickel, S., Entz, L., Ulbert, I., Milham, M. P., Devinsky, O., & Mehta, A. D. Corticocortical Evoked Potentials Reveal Projectors and Integrators in Human Brain Networks. J Neurosci 34, 9152-9163 (2014).
• Entz, L., Tóth, E., Keller, C. J., Bickel, S., Groppe, D. M., Fabó, D., Kozák, L. R., Bognár, L., Wittner, L., Erőss, L., Ulbert, I., & Mehta, A. D. Evoked effective connectivity of the human neocortex. Hum Brain Mapp 35, 5736-5753 (2014).
• Davidesco, I., Zion-Golumbic, E., Bickel, S., Harel, M., Groppe, D. M., Keller, C. J., Schevon, C. A., McKhann, G., Schroeder, C. E., & Mehta, A. D. Exemplar Selectivity Reflects Perceptual Similarities in the Human Fusiform Cortex. Cereb Cortex 24, 1879–1893 (2014).
• Keller, C. et al. Mapping human brain networks with cortico-cortical evoked potentials. Philos. Trans. R. Soc. B: Biol. Sci. 369, 20130528 (2014).
• Mégevand, P. et al. Seeing scenes: topographic visual hallucinations evoked by direct electrical stimulation of the parahippocampal place area. J. Neurosci. 34, 5399–5405 (2014).

Previous Years

• Zion Golumbic, E. M. et al. Mechanisms Underlying Selective Neuronal Tracking of Attended Speech at a “Cocktail Party.” Neuron 77, 980 991 (2013).
• Keller, C. J. et al. Neurophysiological Investigation of Spontaneous Correlated and Anticorrelated Fluctuations of the BOLD Signal. J Neurosci 33, 6333 6342 (2013).
• Keller, C. J. et al. Intrinsic functional architecture predicts electrically evoked responses in the human brain. Proc National Acad Sci 108, 10308 10313 (2011).
• Castellanos, F., Di, M. A., Craddock, R., Mehta, A. & Milham, M. P. Clinical applications of the functional connectome. NeuroImage 80, 527–540 (2013).
• Besle, J. et al. Tuning of the human neocortex to the temporal dynamics of attended events. J. Neurosci. 31, 3176–3185 (2011).
• Mehta, A. & Klein, G. Clinical utility of functional magnetic resonance imaging for brain mapping in epilepsy surgery. Epilepsy Res. 89, 126–132 (2010).
• Keller, C. et al. Heterogeneous neuronal firing patterns during interictal epileptiform discharges in the human cortex. Brain 133, 1668–1681 (2010).
• Mehta, A. et al. Seizure propagation in a patient with musicogenic epilepsy. Epilepsy Behav. 14, 421–424 (2009).
• Sehatpour, P. et al. A human intracranial study of long-range oscillatory coherence across a frontal-occipital-hippocampal brain network during visual object processing. Proc. Natl. Acad. Sci. 105, 4399–4404 (2008).
• Molholm, S. et al. Audio-visual multisensory integration in superior parietal lobule revealed by human intracranial recordings. J. Neurophysiol. 96, 721–729 (2006).